Benign conditions

Non-cancer conditions treated with radiation

Radiation therapy is not only for cancer. Study the major benign conditions treated with radiation — each entry covers the definition, how radiation works against it, side effects, the simulation process, and the treatment process.

Musculoskeletal

Heterotopic ossification prophylaxis

A single post-operative radiation treatment that prevents painful bone formation around a hip or elbow after surgery or trauma.

Definition · Mechanism · Side effects · Simulation · Treatment

Musculoskeletal

Giant cell tumor of bone

A locally aggressive but non-metastatic bone tumor where radiation controls disease in sites that cannot be safely operated on.

Definition · Mechanism · Side effects · Simulation · Treatment

Musculoskeletal

Pigmented villonodular synovitis (diffuse TGCT)

An overgrowth of the joint lining where radiation controls diffuse disease that surgery alone cannot clear.

Definition · Mechanism · Side effects · Simulation · Treatment

Musculoskeletal

Dupuytren contracture and Ledderhose disease

Low-dose radiation that slows the growth of palmar and plantar fibrous nodules before they become fixed contractures.

Definition · Mechanism · Side effects · Simulation · Treatment

Musculoskeletal

Desmoid tumor (aggressive fibromatosis)

A non-metastasizing soft-tissue tumor that relentlessly invades nearby structures, controlled with high-dose conformal radiation.

Definition · Mechanism · Side effects · Simulation · Treatment

Musculoskeletal

Vertebral hemangioma

A common benign spinal blood-vessel tumor that occasionally becomes aggressive and painful, and responds well to moderate-dose radiation.

Definition · Mechanism · Side effects · Simulation · Treatment

Neurologic

Trigeminal neuralgia

Electric-shock facial pain controlled by pinpoint radiosurgery to the trigeminal nerve root, offering a scalpel-free option for refractory cases.

Definition · Mechanism · Side effects · Simulation · Treatment

Benign CNS tumors

Vestibular schwannoma (acoustic neuroma)

A benign inner-ear nerve tumor where focused radiation stops growth while sparing hearing and facial function.

Definition · Mechanism · Side effects · Simulation · Treatment

Benign CNS tumors

Meningioma

The most common benign brain tumor, where radiation controls growth after subtotal resection or replaces surgery at critical skull-base locations.

Definition · Mechanism · Side effects · Simulation · Treatment

Benign CNS tumors

Pituitary adenoma

A benign tumor under the brain where radiation controls growth and, for hormone-secreting tumors, quiets overproduction.

Definition · Mechanism · Side effects · Simulation · Treatment

Benign CNS tumors

Craniopharyngioma

A cystic tumor near the vision and hormone centers of the brain, controlled with radiation after partial removal.

Definition · Mechanism · Side effects · Simulation · Treatment

Neurologic

Brain arteriovenous malformation

A tangle of abnormal brain vessels that radiosurgery gradually seals off over two to three years, eliminating the risk of bleeding.

Definition · Mechanism · Side effects · Simulation · Treatment

Eye and skin

Graves ophthalmopathy (thyroid eye disease)

Inflammation behind the eyes in thyroid disease, quieted by a short course of low-dose orbital radiation that spares the lens.

Definition · Mechanism · Side effects · Simulation · Treatment

Eye and skin

Pterygium

A wing-shaped growth over the eye that is removed surgically, with a strontium-90 plaque treatment preventing it from coming back.

Definition · Mechanism · Side effects · Simulation · Treatment

Eye and skin

Keloids and hypertrophic scars

Raised, expanding scars after surgery or injury that post-excision radiation stops from regrowing.

Definition · Mechanism · Side effects · Simulation · Treatment

Hematologic and other

Gynecomastia prevention

A brief breast dose that prevents painful male breast enlargement caused by prostate cancer hormone therapy.

Definition · Mechanism · Side effects · Simulation · Treatment

Hematologic and other

Splenic irradiation for splenomegaly

Very low daily doses that shrink a painfully enlarged spleen and improve blood counts without removing the organ.

Definition · Mechanism · Side effects · Simulation · Treatment

Hematologic and other

Langerhans cell histiocytosis (bone lesions)

A rare immune-cell disorder where small radiation doses heal painful bone lesions in children and adults.

Definition · Mechanism · Side effects · Simulation · Treatment